The efficacy of immunomodulators in the prevention and suppression of anti-drug antibodies to anti-tumor necrosis factor therapy in inflammatory bowel disease

Authors Fotios S. Fousekis, Konstantinos Papamichael, Georgios Kourtis, Eleni N. Albani, Afroditi Orfanidou, Maria Saridi, Konstantinos H. Katsanos, Dimitrios K. Christodoulou.

Abstract

The development of biological agents against tumor necrosis factor (TNF) has revolutionized the management of inflammatory bowel disease (IBD), frequently achieving induction and maintenance of remission in both ulcerative colitis and Crohn’s disease. However, a loss of response due to  the development of anti-drug antibodies (ADA) is seen annually in approximately 20% of IBD patients receiving anti-TNF therapy. Current evidence suggests that the use of immunomodulators (IMM), such as thiopurines (azathioprine and 6-mercaptopurine) or methotrexate, may preventor suppress ADA formation. In this article, we present a comprehensive review of the availableliterature regarding the efficacy of IMM in the prevention and suppression of ADA development to anti-TNF therapy in patients with IBD.


Keywords anti-TNF, anti-drug antibodies, inflammatory bowel disease, thiopurines, methotrexate


Ann Gastroenterol 2022; 35 (1): 1-7

Published
2022-01-10
Issue
Volume 35, No 1 (2022)
Section
Review Articles