Clarithromycin associated acute pancreatitis

Abstract

Drug-induced acute pancreatitis is known to be caused by a wide range of drugs. We report the development of acute pancreatitis, in a previously healthy female, who developed pneumonia and was receiving clarithromycin, at recommended doses. No other cause of pancreatitis could be identified and the patient was not receiving other drugs. Pancreatitis related symptoms and amylase elevation began 2 days after clarithromycin was initiated and resolved after the drug was discontinued. Available case reports that support the possibility of pancreatotoxicity from macrolides, are discussed. Health care professionals should consider this rare, serious, adverse reaction in patients taking macrolide antibiotics.
Key Words: adverse effects, amylase, antibiotics, clarithromycin,
drug, pancreatitis, pancreatotoxic, macrolides