Isolated Gastric Varices Resulting from Splenic Vein Thrombosis due to Inherited Thrombophilia: Report of a Case

Abstract

Isolated gastric varices mainly occur in individuals with
segmental sinistral portal hypertension, arising from pathology
of the splenic vein, such as thrombosis or stenosis.
We present a patient with acute upper gastrointestinal
bleeding from isolated gastric varices in the absence of liver
or pancreatic pathology. PHT was caused by thrombosis
of the splenic vein due to a hereditary coagulation disorder.
His condition was attributed to Leiden thrombophilia
combined with increased plasma levels of factor VIII. Initial
and subsequent management are presented.
Key Words: Isolated gastric varices, Leiden thrombophilia,
Factor VIII, Injection sclerotherapy, Sugiura procedure