Early effect on intragastric pH of oral administration of rabeprazole with mosapride compared with rabeprazole alone
Background An ideal medication for acid-related diseases would offer prompt stopping of blood flow as well as efficient symptom resolution. The aim of this study was to investigate the gastric acid suppression potency of a single oral dose of rabeprazole alone, compared with administration of rabeprazole plus mosapride.
Methods Twelve male volunteers, Helicobacter pylori (H. pylori)-negative, participated in this randomized, three-way crossover study. After a single oral administration of rabeprazole, rabeprazole with mosapride, or rabeprazole administered 1 h after mosapride, we monitored their intragastric pH constantly for 6 h. A 7-day washout period was allowed between each administration.
Results The median 6-h intragastric pH after the administration of rabeprazole 1 h after mosapride was 4.41Â±1.22 (meanÂ±s.d.), significantly higher than after rabeprazole alone 3.45Â±1.33, P=0.0376). There was no significant difference between the median 6-h pH after the administration of rabeprazole plus mosapride and that after rabeprazole alone (3.81Â±0.98 vs. 3.45Â±1.33, respectively; P=0.0927).
Conclusion An oral dose of rabeprazole administered 1 h after mosapride increased the intragastric pH more rapidly than rabeprazole alone, in healthy, male, H. pylori-negative volunteers.
Keywords Intragastric acidity, rabeprazole, mosapride
Ann Gastroenterol 2017; 30 (4): 424-428