Importance of colonoscopy in patients undergoing endoscopic resection for superficial esophageal squamous cell carcinoma

Kei Tominaga; Hisashi Doyama; Hiroyoshi Nakanishi; Naohiro Yoshida; Yasuhito Takeda; Ryosuke Ota; Kunihiro Tsuji; Kazuhiro Matsunaga; Shigetsugu Tsuji; Kenichi Takemura; Shinya Yamada; Kazuyoshi Katayanagi; Hiroshi Kurumaya

Authors Kei Tominaga, Hisashi Doyama, Hiroyoshi Nakanishi, Naohiro Yoshida, Yasuhito Takeda, Ryosuke Ota, Kunihiro Tsuji, Kazuhiro Matsunaga, Shigetsugu Tsuji, Kenichi Takemura, Shinya Yamada, Kazuyoshi Katayanagi, Hiroshi Kurumaya.

Abstract

Background The aim of the study was to clarify the frequency of colorectal neoplasm (CRN) complicating superficial esophageal squamous cell carcinoma (ESCC) and the need for colonoscopy.

Methods We retrospectively reviewed 101 patients who had undergone initial endoscopic resection (ER) for superficial ESCC. Control group participants were age- andÂ sex-matched asymptomatic subjects screened at our hospital over the same period of time. Advanced adenoma was defined as an adenoma â‰¥10 mm, with villous features, or high-grade dysplasia. Advanced CRN referred to advanced adenoma or cancer. We measured the incidence of advanced CRN in superficial ESCC and controls, and we compared the characteristics of superficial ESCC patients with and without advanced CRN.

Results In the superficial ESCC group, advanced CRNs were found in 17 patients (16.8%). A history of smoking alone was found to be a significant risk factor ofÂ advanced CRN [odds ratio 6.02 (95% CI 1.30-27.8), P=0.005].

Conclusion The frequency of synchronous advanced CRN is high in superficial ESCC patients subjected to ER. Colonoscopy should be highly considered for most patients who undergo ER for superficial ESCC with a history of smoking, and is recommended even in superfi cial ESCC patients.

Keywords Advanced adenoma, colonoscopy, colorectal neoplasm, esophageal squamous cell carcinoma

Ann Gastroenterol 2016; 29 (3): 318-324