Prospective small bowel mucosal assessment immediately after chemoradiotherapy of unresectable locally advanced pancreatic cancer using capsule endoscopy: a case series

Takeshi Yamashina; Ryoji Takada; Noriya Uedo; Tomofumi Akasaka; Noboru Hanaoka; Yoji Takeuchi; Koji Higashino; Tatsuya Ioka; Ryu Ishihara; Teruki Teshima; Hiroyasu Iishi; Hiroyasu Iishi

Authors Takeshi Yamashina, Ryoji Takada, Noriya Uedo, Tomofumi Akasaka, Noboru Hanaoka, Yoji Takeuchi, Koji Higashino, Tatsuya Ioka, Ryu Ishihara, Teruki Teshima, Hiroyasu Iishi, Hiroyasu Iishi.

Abstract

In this case series, three consecutive patients with unresectable locally advanced pancreatic cancer (ULAPC) underwent capsule endoscopy (CE) before and after chemoradiotherapy (CRT) to evaluate duodenal and jejunal mucosa, and to examine the relationship between CE findings and dose distribution. CE after CRT showed duodenitis and proximal jejunitis in all three patients. The most inflamed region was the third part of the duodenum, and in dose distribution, this was the closest region to the center of irradiation. This case series shows that CE can safely diagnose acute duodenitis and proximal jejunitis caused by CRT for ULAPC, and that dose distribution is possible to predict the degree of duodenal and jejunal mucosal injuries.

Keywords Radiation enteritis, capsule endoscopy, pancreatic cancer

Ann Gastroenterol 2016; 29 (3): 386-388