Innate immunity: a new chapter for hepatitis C

Theresa Hydes; Salim I. Khakoo

Authors Theresa Hydes, Salim I. Khakoo.

Abstract

The immune response to hepatitis C virus (HCV) and the mechanisms leading to successful
resolution are complex. Much work has been done on understanding the adaptive immune
response to HCV due to the imperative of trying to find a vaccine. However the importance
of the innate immune system is being increasingly recognized. This has culminated in the
discovery of IL-28B as a key genetic element in recovery from HCV in diverse populations.
This association is one of the strongest in anti-viral immunity and represents a paradigm shift
in how we view the immune response to HCV infection.

Keywords Hepatitis C, immunity, innate, interleukins

Ann Gastroenterol 2012; 25 (2): 232-240