INVITED REVIEW
Small bowel enteroscopy in Crohn’s disease
Tom G. Moreels
University of Antwerp, Belgium
Division of Gastroenterology & Hepatology, Antwerp University Hospital, Belgium
Conflict of Interest: None
Correspondence
to: Tom G. Moreels, Antwerp University Hospital, Division of Gastroenterology
& Hepatology, Wilrijkstraat 10, B-2650 Antwerp, Belgium, Tel: +32-3-821
4974,
Fax: +32-3-821 4478, e-mail: tom.moreels@uza.be
Received 8 August 2011; accepted 10 October 2011
Abstract
Endoscopic assessment of the small bowel is difficult because of its long and tortuous anatomy. However, recent developments have greatly improved the insertion depth and diagnostic yield, by means of device-assisted enteroscopy (DAE). Therefore, DAE may be of specific interest in the diagnostic and therapeutic approach of patients with inflammatory bowel disease. It may be of help in the diagnostic assessment of intestinal disease extent and severity and complications, with an impact on the therapeutic management. Moreover, local treatment within the small bowel is also feasible with DAE. This review aims to provide an overview of the currently available literature data on the use of enteroscopy in inflammatory bowel disease, and Crohn’s disease in particular.
Keywords inflammatory bowel disease, Crohn’s disease, enteroscopy, device-assisted enteroscopy, review
Ann Gastroenterol 2012; 25 (1): 14-20
Introduction
Inflammatory bowel disease (IBD) encompasses Crohn’s disease (CD), ulcerative colitis (UC) and IBD of unclassified type (IBDU) [1]. UC is confined to the colon whereas CD can occur throughout the entire gastrointestinal (GI) tract with the highest prevalence at the ileocecal junction. Assessment of the small bowel is of specific interest in case of CD and to further differentiate the diagnosis of IBDU. Small bowel involvement of CD is mostly confined to the (terminal) ileum. However, proximal intestinal inflammation can occur in 10% of the patients with normal segments interspersed between pathological lesions [2]. The diagnosis of CD is based on the combination of clinical suspicion, biochemical parameters, radiological and endoscopic lesions and specific histopathological criteria. It is necessary to perform both upper GI endoscopy visualizing the esophagus, stomach and duodenum and lower GI endoscopy visualizing the colon and if possible the terminal ileum [3].
In case of suspected extended intestinal involvement or complicated intestinal disease like stenosis, fistula and malignancy or in case of IBDU, several diagnostic options are available to assess the small bowel [2-5]. Radiology and endoscopy are complementary techniques to define the extent of disease and to detect intestinal complications. This review focuses on the currently available data on small bowel endoscopy (enteroscopy) in Crohn’s disease.
Radiology
Until a decade ago, visualization of the small bowel was generally performed with classical barium follow-through or enteroclysis with a nasojejunal tube [6]. These radiological techniques allow determination of the extent of intestinal involvement and complications like stenosis with proximal dilation, fistula and malignancy. However, because of better accuracy, enterography or enteroclysis by means of computed tomography (CT) or magnetic resonance imaging (MRI) are currently the preferred radiological techniques to assess CD small bowel involvement [2]. In addition to the disease extent, CT and MRI can also assess the disease activity, based on wall thickness and intravenous contrast enhancement, and the presence of extraluminal disease. Apart from the excellent diagnostic accuracy, CT and MRI enterography/enteroclysis envision drawbacks because of patient’s discomfort (forced bowel distension and nasojejunal tube placement), radiation exposure (CT), availability (MRI) and their merely diagnostic nature [7]. In some centers, small bowel ultrasound, with or without Doppler is also used to assess ileal involvement of CD, but this diagnostic technique is very operator dependent [8].
Endoscopy
In addition to radiological methods, new endoscopic techniques have emerged to evaluate the small bowel [9]. The advantage of enteroscopy over radiological enterography is its real-time viewing and its therapeutic potential, ranging from mucosal biopsy sampling, local hemostasis, balloon dilation of stenosis and even fistula closure. The history of enteroscopy started in the 1970’s and became more routinely used with the development of push-enteroscopy (PE) and intra-operative enteroscopy in the 1980’s. The main disadvantages of these conventional enteroscopy techniques are the inability to visualize the entire small bowel (push-enteroscopy) and the invasiveness (intra-operative enteroscopy).
Wireless capsule enteroscopy: To deal with the problem of incomplete visualization of the small bowel, non-invasive wireless capsule enteroscopy (WCE) was developed and became available in 2000, enabling complete endoscopic visualization of the small bowel in an elegant way. Since then numerous new WCE developments have emerged, like improved image quality, number of images recorded per second, battery life duration and the software to read the images [10]. It has been shown that WCE is more accurate to detect small and superficial mucosal CD lesions as compared to radiological techniques, but suspicion of small bowel stenosis is a contraindication because of the risk of capsule retention [3,11,12]. Recent guidelines by ECCO (European Crohn’s and Colitis Organisation), ESGE (European Society of Gastrointestinal Endoscopy) and OMED (World Organisation of Digestive Endoscopy) have established the role of WCE in the assessment of IBD: it is useful in patients with high clinical suspicion of CD despite negative radiological and conventional upper and lower GI endoscopy or in case of further differentiation of IBDU [2,11-14]. Moreover, WCE can be useful in the setting of established CD with unexplained symptoms like persistent anemia, abdominal pain or malabsorption [14]. In case of recurrent abdominal pain, intestinal stricture should be excluded before WCE can be safely performed [3]. A normal WCE examination has a high negative predictive value for active small bowel CD [2].
Enteroscopy: Parallel to the development of the still merely diagnostic WCE, conventional push-enteroscopy via the oral route was also subjected to a new evolution in order to perform all conventional endoscopic interventions throughout the entire small bowel [9]. Device-assisted enteroscopy (DAE) improves enteroscopy performance by means of specialized overtubes (Fig. 1). The use of a semi-rigid overtube allows deeper intubation of the jejunum because it helps to straighten the enteroscope avoiding jejunal stretching [15]. However, overtube-guided push-enteroscopy only allows peroral intubation of the jejunum without complete enteroscopy [16].
The concept of balloon-assisted enteroscopy is a second breakthrough in the evolution of DAE and can be performed via the oral and the anal route [9]. Both double- and single-balloon enteroscopy (DBE and SBE) are currently widely available. The addition of an inflatable balloon at the distal end of the overtube with (DBE) or without (SBE) a second inflatable balloon at the tip of the enteroscope allows better mucosal grip of the enteroscope and overtube stabilizing its position within the intestinal lumen. Both balloon-assisted methods are based upon the push-and-pull principle [17,18]. It is a stepwise progression of the enteroscope through the small intestine with the balloon-loaded overtube used as a straightening device. Both balloon-assisted methods allow deep and even complete intubation of the small bowel within a reasonable procedure time, although often a combined approach through the mouth and the anus is necessary to complete enteroscopy [17,18]. In addition, all conventional endoscopic interventions, ranging from mucosal tissue sampling, local hemostasis, polypectomy and balloon dilation, can now be performed throughout the length of the small bowel thanks to balloon-assisted enteroscopy.
Next to balloon-assisted enteroscopy, spiral overtube enteroscopy (SE) is the most recent development of DAE. It also allows rapid and deep intubation of the small bowel through the oral and anal route [19]. The enteroscope remains in a stable position and by rotating the overtube with its raised helices, the small bowel is pulled backwards over the enteroscope. Primary results of recent comparative studies between DBE, SBE and SE show that all three DAE methods allow comparable insertion depths with similar diagnostic yields and low complication rates [18,20,21].
Enteroscopy in Crohn’s disease
Current guidelines: Endoscopic investigation of the small bowel is not indicated in every patient with IBD. ECCO and OMED guidelines state that DAE should be used when intestinal tissue samples for pathological examination are needed when conventional radiological and endoscopic imaging have been inconclusive or when therapeutic manoeuvres are required [2,13,14]. However, these guidelines are mostly graded levels C and D (based upon case series and expert opinion).
Current literature: Recent studies also suggest that endoscopic small bowel assessment may have impact on future therapy, both medically and surgically. Local therapy appears feasible under the form of intestinal stricture balloon dilation or submucosal injection of anti-inflammatory drugs in strictures. Finally, enteroscopic retrieval of a retained WCE capsule has been described several times due to CD intestinal stricture (Fig. 2). Most published patient series on DAE focus on small bowel pathology in general and obscure GI bleeding in particular. Therefore, they also include some patients with IBD and (suspected) CD. Only a limited number of studies was specifically designed (both retrospectively and prospectively) to assess the role of DAE in CD. An overview is provided in Table 1.
Interpretation of the literature: Review of the literature reveals several interesting and promising aspects of DAE in CD. Most data are available for DBE, but also conventional PE and the more recent SBE and SE can be useful for the assessment or treatment of the small bowel in CD, even in the pediatric population. Apart from PE, only performed via the oral route, all other DAE procedures can be used both orally and anally, significantly increasing the diagnostic and therapeutic yield. Indications to perform DAE in CD appear wider than suggested in the recent ECCO, ESGE and OMED guidelines [2,13,14]. Unexplained anemia, hypomagnesemia, chronic diarrhea or recurrent obscure GI bleeding can be caused by (undiagnosed) CD small bowel lesions, which can now be reached by DAE [22,23,33,35]. Moreover, local hemostasis is also feasible during enteroscopy, rendering DAE an interesting tool for this indication. Also screening for CD-related small bowel malignancy, under the form of adenocarcinoma, lymphoma and carcinoid tumor, can be performed by DAE [31,32,42]. Tables 2 and 3 demonstrate the endoscopic grading scales that have been established to describe the appearance of intestinal CD lesions and to grade the severity of disease activity (Fig. 3) [33,41]. Uniformity in description of lesions is important for several reasons: comparison between different patients, comparison between different time-points in the same patient (effect of therapy), development of a standardized severity scale with prognostic value, validated scales are necessary for multicenter interventional trials. Future studies should validate these endoscopic grading scales and evaluate their clinical usefulness. Several studies have shown that DAE may have an impact on the therapeutic strategies in CD, leading to clinical, biochemical and endoscopic improvement [22,24-27,29,32,33,35,36,39,40]. Also, postoperative intestinal CD recurrence can be adequately assessed with DAE, and may prove useful in therapeutic decision making, both in pediatric and adult patients [32,36,40]. To avoid surgical intervention in case of clinically important intestinal strictures, (repeated) enteroscopic balloon dilation can be advised for a non-ulcerative stricture of no longer than 4-6 cm [23,26,27,30,33,38,40,41]. In case of long or inflammatory strictures, balloon dilation may significantly increase the risk of perforation [41]. Therefore, inflammatory and ulcerative strictures should be primarily treated by rigorous medical therapy. Several cases have described retained WCE due to intestinal CD strictures, successfully removed by DAE, again avoiding surgical intervention [25,30,34,37]. Finally, local injection of immunomodulatory drugs like corticosteroids and the anti-tumor-necrosis-factor-á antibody infliximab in the four quadrants of CD stricture may become a potentially interesting therapeutic strategy [43].
Complications: In general, diagnostic DAE has a low complication rate of less than 1%, mainly presented as post-procedural abdominal pain and pancreatitis after an oral procedure [44,45]. Complication rates of therapeutic DAE may reach up to 5%, with a substantial risk of bleeding and perforation [44,45]. Perforation may occur after intestinal polypectomy, after Argon plasma coagulation of intestinal arteriovenous malformations and after balloon dilation of intestinal strictures. In CD more specifically, complication rates tend to be higher, especially in patients with a history of intestinal surgery, in whom perforation may occur even in merely diagnostic DAE procedures, and after balloon dilation of intestinal strictures [25,30,37]. However, DAE in pediatric (postoperative) Crohn’s disease does not appear to have a higher complication risk [40].
Future directions: Since levels of evidence in current guidelines are mainly graded C and D and since currently available literature has only highlighted some aspects of DAE in CD, future research should aim to provide a more definite answer to the following remaining questions:
What is the clinical validity of currently available grading scales of mucosal lesions and severity of disease?
What is the definite position of DAE in the diagnostic evaluation of (postoperative) intestinal CD (in relation to radiology and WCE)?
What is the impact of diagnostic DAE on therapeutic strategies for CD?
How often should DAE be performed in CD?
Should DAE be used as screening for small bowel malignancy in CD?
What is the local therapeutic potential of DAE in small bowel CD?
What is the safety and complication rate of DAE in (postoperative) CD?
Should every gastroenterologist treating IBD patients also perform DAE?
Can the diagnostic and therapeutic yield of DAE in CD be improved with newer developments?
What is the position of DAE in the pediatric CD population?
Conclusions
The small bowel has regained much attention since the development of WCE in the year 2000. Since then, both new radiological and endoscopic techniques have emerged to explore the small bowel. DAE is an innovative and still developing endoscopic procedure enabling deep and even complete enteroscopy. The design of specialized overtubes was shown to be of major importance in this development. Nowadays, both single- and double-balloon enteroscopy are widely available and have been shown to be equally effective. Also the spiral overtube enables fast and deep enteroscopy. With the help of these different DAE methods, all conventional endoscopic interventions like biopsy sampling, local hemostasis, polypectomy etc. are now possible throughout the length of the small bowel.
Since IBD, and CD in particular, often affect the small bowel, DAE may be useful in the assessment of the intestine. Previously, ECCO, ESGE and OMED have defined guidelines on the use of DAE in IBD. However, most of these guidelines are based on case series and expert opinion (evidence levels C and D). This review provided an overview of the currently available literature data on the use of DAE in IBD. The majority of studies are retrospective case series with only a few prospective trials. However, they provide preliminary but promising answers to pertinent questions regarding both the diagnostic and therapeutic potential and safety of DAE in CD. Future research should aim to consolidate the role of DAE in IBD and to further improve the procedure of DAE.
References
1. Podolsky D. Inflammatory bowel disease. N Engl J Med 2002;347:417-429.
2. Van Assche G, Dignass A, Panes J, et al. The second European evidence-based consensus on the diagnosis and management of Crohn’s disease: definitions and diagnosis. J Crohns Colitis 2010;4:7-27.
3. Sidhu R, Sanders DS, Morris AJ, McAlindon ME. Guidelines on small bowel enteroscopy and capsule endoscopy in adults. Gut 2008;57:125-136.
4. Herfarth HH, Long MD. Capsule and balloon endoscopy: when are they really needed in patients with inflammatory bowel diseases? Dig Dis 2010;28:439-444.
5. Murphy SJ, Kornbluth A. Double balloon enteroscopy in Crohn’s disease: where are we now and where should we go? Inflamm Bowel Dis 2011;17:485-490.
6. Maglinte DDT, Kelvin FM, O’Connor K, Lappas JC, Chernish SM. Current status of small bowel radiography. Abdom Imaging 1996;21:247-257.
7. Lee SS, Kim AY, Yang SK, et al. Crohn disease of the small bowel: comparison of CE enterography, MR enterography, and small-bowel follow-through as diagnostic techniques. Radiology 2009;251:751-761.
8. Schreyer AG, Menzel C, Friedrich C, et al. Comparison of high-resolution ultrasound and MR-enterography in patients with inflammatory bowel disease. World J Gastroenterol 2011;17:1018-1025.
9. Moreels TG. History of endoscopic devices for the exploration of the small bowel. Acta Gastroenterol Belg 2009;72:335-337.
10. Lee NM, Eisen GM. 10 Years of capsule endoscopy: an update. Expert Rev Gastroenterol Hepatol 2010;4:503-512.
11. Triester SL, Leighton JA, Leontiadis GI, et al. A meta-analysis of the yield of capsule endoscopy compared to other diagnostic modalities in patients with non-stricturing small bowel Crohn’s disease. Am J Gastroenterol 2006;101:954-964.
12. Dionisio PM, Gurudu SR, Leighton JA, et al. Capsule endoscopy has a significantly higher diagnostic yield in patients with suspected and established small-bowel Crohn’s disease: a meta-analysis. Am J Gastroenterol 2010;105:1240-1248.
13. Pohl J, Delvaux M, Ell C, et al. European Society of Gastrointestinal Endoscopy (ESGE) guidelines: flexible enteroscopy for diagnosis and treatment of small-bowel diseases. Endoscopy 2008;40:609-618.
14. Bourreille A, Ignjatovic A, Aabakken L, et al. Role of small-bowel endoscopy in the management of patients with inflammatory bowel disease: an international OMED-ECCO consensus. Endoscopy 2009;41:618-637.
15. Shimizu S, Tada M, Kawai K. Development of a new insertion technique in push-type enteroscopy. Am J Gastroenterol 1987;82:844-847.
16. Wilmer A, Rutgeerts P. Push enteroscopy. Technique, depth, and yield of insertion. Gastrointest Clin N Am 1996;6:759-776.
17. Mönkemüller K, Fry LC, Bellutti M, Malfertheiner P. Balloon-assisted enteroscopy: unifying double-balloon and single-balloon enteroscopy. Endoscopy 2008;40:537.
18. Buscaglia JM, Okolo PI. Deep enteroscopy: training, indications, and the endoscopic technique. Gastrointest Endosc 2011;73:1023-1028.
19. Mensink PBF. Spiral enteroscopy: from “new kid on the block” to established deep small-bowel enteroscopy tool. Endoscopy 2010;42:955-956.
20. May A, Färber M, Aschmoneit I, et al. Prospective multicenter trial comparing push-and-pull enteroscopy with the single- and double-balloon techniques in patients with small-bowel disorders. Am J Gastroenterol 2010;105:575-581.
21. Domagk D, Mensink P, Aktas H, et al. Single- vs. double-balloon enteroscopy in small-bowel diagnostics: a randomized multicenter trial. Endoscopy 2011;43:472-476.
22. Perez-Cuadrado E, Macenlle R, Iglesias J, Fabra R, Lamas D. Usefulness of oral video push enteroscopy in Crohn’s disease. Endoscopy 1997;29:745-747.
23. Perez-Cuadrado E, Molina Perez E. Multiple strictures in jejunal Crohn’s disease: push enteroscopy dilation. Endoscopy 2001;33:S194.
24. Chong AKH, Taylor A, Miller A, Hennessy O, Connell W, Desmond P. Capsule endoscopy vs. push enteroscopy and enteroclysis in suspected small-bowel Crohn’s disease. Gastrointest Endosc 2005;61:255-261.
25. Oshitani N, Yukawa T, Yamagami H, et al. Evaluation of deep small bowel involvement by double-balloon enteroscopy in Crohn’s disease. Am J Gastroenterol 2006;101:1484-1489.
26. Gay G, Delvaux M. Double balloon enteroscopy in Crohn’s disease and related disorders: our experience. Gastrointest Endosc 2007;66:S82-S90.
27. Pohl J, May A, Nachbar L, Ell C. Diagnostic and therapeutic yield of push-and-pull enteroscopy for symptomatic small bowel Crohn’s disease strictures. Eur J Gastroenterol Hepatol 2007;19:529-534.
28. Seiderer J, Herrmann K, Diepolder H, et al. Double-balloon enteroscopy versus magnetic resonance enteroclysis in diagnosing suspected small-bowel Crohn’s disease: results of a pilot study. Scand J Gastroenterol 2007;42:1376-1385.
29. Semrad C. Role of double balloon enteroscopy in Crohn’s disease. Gastrointest Endosc 2007;66:S94-S95.
30. Despott EJ, Gupta A, Burling D, et al. Effective dilation of small-bowel strictures by double-balloon enteroscopy in patients with symptomatic Crohn’s disease. Gastrointest Endosc 2009;70:1030-1036.
31. Kodaira C, Osawa S, Mochizuki C, et al. A case of small bowel adenocarcinoma in a patient with Crohn’s disease detected by PET/CT and double-balloon enteroscopy. World J Gastroenterol 2009;14:1774-1778.
32. Manes G, Imbesi V, Ardizzone S, Cassinotti A, Pallotta S, Bianchi Porro G. Use of double-balloon enteroscopy in the management of patients with Crohn’s disease: feasibility and diagnostic yield in a high-volume centre for inflammatory bowel disease. Surg Endosc 2009;23:2790-2795.
33. Mensink PBF, Groenen MJ, van Buuren HR, Kuipers EJ, van der Woude CJ. Double-balloon enteroscopy in Crohn’s disease patients suspected of small bowel activity: findings and clinical impact. J Gastroenterol 2009;44:271-276.
34. Zuber-Jerger I, Gelbmann CM, Endlicher E, Ott C, Obermeier F. Complicated wireless capsule enteroscopy in a patient with Crohn’s disease. Eur J Gastroenterol Hepatol 2009;21:952-954.
35. Mensink PBF, Aktas H, Zelinkova Z, West RL, Kuipers EJ, van der Woude CJ. Impact of double-balloon enteroscopy findings on the management of Crohn’s disease. Scand J Gastroenterol 2010;45:483-489.
36. Naganuma M, Watanabe M, Hibi T. Safety and usefulness of balloon endoscopy in Crohn’s disease patients with postoperative ileal lesions. J Crohns Colitis 2011;5:73-74.
37. Sharma MK, Sharma P, Garg H, Sehgal L, Bhatia V. Clinical acute pancreatitis following anterograde single balloon enteroscopy. Endoscopy 2011;43:E20-E21.
38. Story B, Thirlby R, Schembre D. Diagnosis of ileal dysplasia in a patient with Crohn’s disease by using retrograde enteroscopy using an overtube: a case report. Gastrointest Endosc 2011;73:178-179.
39. Zhou N, Chen WX, Chen SH, Xu CF, Li YM. Inflammatory bowel disease unclassified. J Zhejiang Univ-Sci B 2011;12:280-286.
40. Di Nardo G, Oliva S, Aloi M, et al. Usefulness of single-balloon enteroscopy in pediatric Crohn’s disease. Gastrointest Endosc 2011 (in press)
41. Sunada K, Yamamoto H, Yano T, Sugano K. Advances in the diagnosis and treatment of small bowel lesions in Crohn’s disease using double-balloon endoscopy. Ther Adv Gastroenterol 2009;2:357-366.
42. DiLauro S, Crum-Cianflone NF. Ileitis: when it is not Crohn’s disease. Curr Gastroenterol Rep 2010;12:249-258.
43. Kochhar R, Poornachandra KS. Intralesional steroid injection therapy in the management of resistant gastrointestinal strictures. World J Gastrointest Endosc 2010;2:61-68.
44. Mensink PBF, Haringsma J, Kucharzik T, et al. Complications of double-balloon enteroscopy: a multicenter survey. Endoscopy 2007;39:613-615.
45. Lo SK. Techniques, tricks, and complications of enteroscopy. Gastrointest Endosc Clin N Am 2009;19:381-388.